Revive: CLINICAL RESULTS

CLINICAL RESULTS.

The ingredients and quantities in REVIVE are proven in randomized placebo-controlled clinical trials. But don’t just take our word for it. See for yourself how these compounds were tested and what the results showed.

Revive Chart

 

SLEEP QUALITY & EFFICIENCY.

Four separate clinical studies have established glycine, L-theanine and L-ornithine’s ability to significantly improve quality of sleep. Studies employed a range of methodologies to assess sleep quality, including sleep efficiency, wakefulness after sleep onset and sleep satisfaction.
Actigraphy

Trial subjects wore a wrist-mounted accelerometer device during sleep to record sleep efficiency, duration, latency and patterns. Subjects in the L-theanine group recorded significantly higher sleep efficiency and significantly lower amounts of wakefulness after sleep onset.

Theanine Sleep Efficiency 200Theanine WASO 200

Source: Ozeki et al (2004), Rao et al (2015)

A separate study investigated the effects of a higher dosage of L-theanine (400mg) on sleep quality in children with ADHD. Again, subjects in the L-theanine group recorded significantly higher sleep efficiency, as well as significantly fewer discreet bouts of nocturnal activity and a near-significant reduction in minutes of wakefulness after sleep onset.

 Theanine Sleep Efficiency 400Theanine WASO

Source: Lyon et al (2011)
 

St Mary's Hospital Sleep Questionnaire

The SMH sleep questionnaire is a systematic survey for assessing the previous night’s sleep of a subject. Trial subjects receiving glycine reported significantly higher sleep efficiency (ratio of sleep time to whole time in bed) and satisfaction with their sleep compared to placebo.

Glycine Sleep Efficiency Sleep Satisfaction

Source: Yamadera et al (2007) 


Athens Insomnia Scale (AIS)

The AIS is a self-assessment psychometric instrument designed for quantifying sleep quality. Subjects rank each item on a scale of 0-4: difficulty with sleep induction, awakening during the night, early morning awakening, total sleep time, overall quality of sleep, sense of well-being, physical and mental functioning, and daytime sleepiness. Higher scores indicate lower quality sleep. Subjects receiving L-ornithine reported significantly improved scores compared to placebo. Subjects were evaluated on a weekly basis, with consistently improved results.

Change in AIS Score 

Source: Miyake et al (2014)

SLEEP ONSET:

Three separate clinical studies have established glycine and L-ornithine’s ability to significantly reduce the time it takes to initiate sleep. Studies employed a range of methodologies to assess latency to sleep onset. 

Polysomnography

Polysomnography is a comprehensive recording of the biophysiological changes that occur during sleep. Trial subjects were connected to electrodes to measure the time taken to achieve different stages of sleep. Glycine ingestion consistently shortened latency to all sleep stages (although latency to REM was not statistically significant). 

Glycine latency

Source: Yamadera et al (2007)

 

St Mary's Hospital Sleep Questionnaire

The SMH sleep questionnaire is a systematic survey for assessing the previous night’s sleep of a subject. Trial subjects receiving glycine reported that they had fallen asleep more quickly and had less difficulty falling asleep compared to placebo.

glycine how many minutes Glycine how much difficult

Source: Yamadera et al (2007) 


OSA Sleep Inventory

The OSA sleep inventory is a survey commonly used in Japan for evaluation of sleep quality. Trial subjects receiving L-ornithine reported improved scores for “initiation and maintenance of sleep” and “sleep length” compared to placebo. Subjects were evaluated on a weekly basis, with consistently improved results.

Ornithine Initiation MaintenceOrnithine Sleep Length 

Source: Miyake et al (2014)

 

NEXT-DAY FATIGUE & COGNITIVE FUNCTION.

Three separate clinical studies have established that taking glycine before bedtime can enhance next-day cognitive function and reduce symptoms of fatigue. Studies employed a range of different methodologies to assess daytime sleepiness, daytime fatigue and cognitive function.

Visual Analog Scale (VAS)

VAS is a psychometric response scale which can be used in questionnaires. When responding to a VAS item, respondents specify their level of agreement to a statement by indicating a position along a continuous line between two end-points, corresponding to a score between 0 and 100. In two separate studies, subjects have reported significantly lower daytime fatigue and daytime sleepiness the day after taking glycine at bedtime.

VAS Daytime FatigueVAS Daytime Sleepiness


Performance Test Program

A commercial computerized test battery evaluating a broad range of cognitive functioning. The study sought to evaluate the impact of glycine on sleep-restricted individuals. Subjects were restricted to 75% of their normal amount of sleep time. Subjects taking glycine showed a tendency towards improvement across all tests, with statistically significant improvement seen in the psychomotor vigilance test.


St Mary's Hospital Sleep Questionnaire and Space-Aeromedicine Fatigue Checklist

Another study used the SMH and SAM surveys to evaluate next-day fatigue. Subjects taking 3g glycine reported significantly improved  “fatigue”, “liveliness and peppiness” and “clear-headedness” compared to placebo.

Source: Inagawa et al (2006)

 

Non-Sedative 

Many natural and herbal sleep aids act by sedating the user to induce sleepiness. This can cause various side effects including a residual sedative effect upon waking (“morning grogginess”). Ultimately the user may become dependent on sedatives to achieve sleep. Studies show that taking L-theanine or glycine during the day does not induce feelings of sleepiness, unlike a traditional hypnotic sedative which will induce sleep regardless of the time of day it is taken. These substances are therefore non-sedative. 

Visual Analog Scale (VAS)

Subjects were administered with L-theanine in either the morning or the afternoon to evaluate the impact on sleepiness and alertness from daytime consumption of L-theanine. The study showed that subjects in the L-theanine group were more alert and less sleepy than those in the placebo group, demonstrating that L-theanine’s mechanism of action relating to sleep is non-sedative. 

Theanine AlertnessTheanine Absence of Sleepiness

Source: Ozeki et al (2008), Rao et al (2015)


Jikaku-Sho Shirabe Questionnire

Jikaku-Sho Shirabe is a questionnaire that enables respondents to self-report feelings of fatigue. Subjects were given 9g of glycine (REVIVE contains only 3g glycine) either at bedtime or during the daytime. There was no significant difference in daytime sleepiness between control (no treatment), placebo or glycine in daytime sleepiness, demonstrating that glycine’s mechanism of action relating to sleep is non-sedative.

Glycine 9G Sleepiness

Source: Inagawa et al (2006) 

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